The rise and fall of XMRV
Identifieur interne : 001A45 ( Main/Exploration ); précédent : 001A44; suivant : 001A46The rise and fall of XMRV
Auteurs : O. K. Kakisi [Royaume-Uni] ; M. J. Robinson ; K. I. Tettmar [Royaume-Uni] ; R. S. Tedder [Royaume-Uni]Source :
- Transfusion Medicine [ 0958-7578 ] ; 2013-06.
English descriptors
- Teeft :
- Advisory committee, Authors transfusion medicine, Biomedical research, Blood cells, Blood donation, Blood safety, Blood supply, Blood transfusion, British blood transfusion society, Cell culture, Cell line, Cell lines, Chronic fatigue syndrome, Contamination, Contamination origin, Current history, Deferral, Donor, Endogenous, Endogenous retroviruses, Feeder, Gammaretrovirus, Gammaretroviruses, Healthy blood donors, Human cells, Human pathogen, Human population, Leukemia, Lombardi, Microbiology, Mlvs, Molecular biology, Mouse cells, Multiple sclerosis, Murine, National academy, Nhsbt, Nude mice, Pathogen, Plo, Prostate, Prostate cancer, Provirus, Public health, Recombination, Retroviral, Retrovirology, Retrovirus, Syndrome, Transfusion, Transfusion medicine, Transfusion services, Viral, Virology, Virus, Xenotropic, Xenotropic murine leukaemia virus, Xenotropic murine leukemia virus, Xmrv, Xmrv infection.
Abstract
Due to the relatively recent emergence of the human T‐lymphotropic and the human immunodeficiency viruses, enthusiasm for the identification of novel viruses, especially retroviruses, with pathogenic potential in humans, remains high. Novel technologies are now available with the ability to search for unknown viruses, such as gene arrays and new generation sequencing of tissue and other samples. In 2006, chip technology identified a novel retrovirus in human prostate cancer (PCa) tissue samples. Due to close homology to a mouse retrovirus, the virus was named xenotropic murine leukaemia virus‐related virus (XMRV). Ever since the initial disease association with PCa, XMRV has stirred a lot of attention and concern worldwide for the medical community, public health officials and in particular global transfusion services. Public response, in this new era of electronic communication and advocacy was rapid, wide and unprecedented. In this review, we outline the course of biomedical research efforts that were put forward internationally in the process of determining the risk to the human population, the response of the blood banking community and review the current state of knowledge of xenotropic murine retroviruses. Although XMRV is no longer regarded as an infection of humans, a lesson was learnt in modern virology that holds deeper implications for biomedical research, particularly stem cell generation and transplantation practices.
Url:
DOI: 10.1111/tme.12049
Affiliations:
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Novel technologies are now available with the ability to search for unknown viruses, such as gene arrays and new generation sequencing of tissue and other samples. In 2006, chip technology identified a novel retrovirus in human prostate cancer (PCa) tissue samples. Due to close homology to a mouse retrovirus, the virus was named xenotropic murine leukaemia virus‐related virus (XMRV). Ever since the initial disease association with PCa, XMRV has stirred a lot of attention and concern worldwide for the medical community, public health officials and in particular global transfusion services. Public response, in this new era of electronic communication and advocacy was rapid, wide and unprecedented. In this review, we outline the course of biomedical research efforts that were put forward internationally in the process of determining the risk to the human population, the response of the blood banking community and review the current state of knowledge of xenotropic murine retroviruses. Although XMRV is no longer regarded as an infection of humans, a lesson was learnt in modern virology that holds deeper implications for biomedical research, particularly stem cell generation and transplantation practices.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><noCountry><name sortKey="Robinson, M J" sort="Robinson, M J" uniqKey="Robinson M" first="M. J." last="Robinson">M. J. Robinson</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kakisi, O K" sort="Kakisi, O K" uniqKey="Kakisi O" first="O. K." last="Kakisi">O. K. Kakisi</name></region><name sortKey="Kakisi, O K" sort="Kakisi, O K" uniqKey="Kakisi O" first="O. K." last="Kakisi">O. K. Kakisi</name><name sortKey="Tedder, R S" sort="Tedder, R S" uniqKey="Tedder R" first="R. S." last="Tedder">R. S. Tedder</name><name sortKey="Tedder, R S" sort="Tedder, R S" uniqKey="Tedder R" first="R. S." last="Tedder">R. S. Tedder</name><name sortKey="Tettmar, K I" sort="Tettmar, K I" uniqKey="Tettmar K" first="K. I." last="Tettmar">K. I. Tettmar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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